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The relevance of EMT in breast cancer metastasis: Correlation or causality?

Bill, Ruben and Christofori, Gerhard. (2015) The relevance of EMT in breast cancer metastasis: Correlation or causality? FEBS letters, 589 (14). pp. 1577-1587.

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Official URL: http://edoc.unibas.ch/42991/

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Abstract

Although major progress has been achieved in treating breast cancer patients, metastatic breast cancer still remains a deadly disease. A full understanding of the process of systemic cancer cell dissemination is therefore critical to develop next generation therapies. A plethora of experimental data points toward a central role of an epithelial to mesenchymal transition (EMT) in the multistep cascade of metastasis formation. However, in patients the data are based on correlative studies which often, but not always, tie the expression of EMT markers to cancer invasion, metastasis and poor clinical outcome. Moreover, the notion that cancer cells are able to switch between different modes of migration asks for a thorough review of the actual relevance of EMT in cancer metastasis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Tumor Biology (Christofori)
UniBasel Contributors:Christofori, Gerhard M.
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Elsevier Science
ISSN:0014-5793
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:01 Dec 2016 07:12
Deposited On:01 Dec 2016 07:12

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