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Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

Syed, Durafshan Sakeena and Gowda, Swetha B.M. and Reddy, O. Venkateswara and Reichert, Heinrich and VijayRaghavan, K.. (2016) Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking. eLife, 5. e11572.

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Official URL: http://edoc.unibas.ch/42155/

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Abstract

Motoneurons developmentally acquire appropriate cellular architectures that ensure connections with postsynaptic muscles and presynaptic neurons. In Drosophila, leg motoneurons are organized as a myotopic map, where their dendritic domains represent the muscle field. Here we investigate mechanisms underlying development of aspects of this myotopic map, required for walking. A behavioral screen identified roles for Semaphorins (Sema) and Plexins (Plex) in walking behavior. Deciphering this phenotype, we show that PlexA/Sema1a mediates motoneuron axon branching in ways that differ in the proximal femur and distal tibia, based on motoneuronal birth order. Importantly, we show a novel role for glia in positioning dendrites of specific motoneurons; PlexB/Sema2a is required for dendritic positioning of late-born motoneurons but not early-born motoneurons. These findings indicate that communication within motoneurons and between glia and motoneurons, mediated by the combined action of different Plexin/Semaphorin signaling systems, are required for the formation of a functional myotopic map.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Zoology (Reichert)
UniBasel Contributors:Reichert, Heinrich
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:eLife Sciences Publications
ISSN:2050-084X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Sep 2016 06:37
Deposited On:29 Sep 2016 06:37

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