edoc

Menopause as a predictor of new-onset asthma : a longitudinal northern European population study

Triebner, Kai and Johannessen, Ane and Puggini, Luca and Benediktsdóttir, Bryndís and Bertelsen, Randi J. and Bifulco, Ersilia and Dharmage, Shyamali C. and Dratva, Julia and Franklin, Karl A. and Gíslason, Thórarinn and Holm, Mathias and Jarvis, Deborah and Leynaert, Bénédicte and Lindberg, Eva and Malinovschi, Andrei and Macsali, Ferenc and Norbäck, Dan and Omenaas, Ernst R. and Rodríguez, Francisco J. and Saure, Eirunn and Schlünssen, Vivi and Sigsgaard, Torben and Skorge, Trude D. and Wieslander, Gunilla and Zemp, Elisabeth and Svanes, Cecilie and Hustad, Steinar and Gómez Real, Francisco. (2016) Menopause as a predictor of new-onset asthma : a longitudinal northern European population study. Journal of allergy and clinical immunology, 137 (1). pp. 50-57.e6.

[img]
Preview
PDF - Published Version
Available under License CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives).

483Kb

Official URL: http://edoc.unibas.ch/41982/

Downloads: Statistics Overview

Abstract

There is limited and conflicting evidence on the effect of menopause on asthma.; We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.; The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.; The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.; New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Society, Gender and Health > Gender and Health (Zemp Stutz)
UniBasel Contributors:Zemp Stutz, Elisabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Mosby
ISSN:0091-6749
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:02 Nov 2017 07:08
Deposited On:19 Apr 2016 12:27

Repository Staff Only: item control page