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Dynamics of membrane proteins within synthetic polymer membranes with high hydrophobic mismatch

Itel, Fabian and Najer, Adrian and Palivan, Cornelia and Meier, Wolfgang. (2015) Dynamics of membrane proteins within synthetic polymer membranes with high hydrophobic mismatch. Nano Letters, 15 (6). pp. 3871-3878.

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Official URL: http://edoc.unibas.ch/41922/

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Abstract

The functioning of biological membrane proteins (MPs) within synthetic block copolymer membranes is an intriguing phenomenon that is believed to offer great potential for applications in life and medical sciences and engineering. The question why biological MPs are able to function in this completely artificial environment is still unresolved by any experimental data. Here, we have analyzed the lateral diffusion properties of different sized MPs within poly(dimethylsiloxane) (PDMS)-containing amphiphilic block copolymer membranes of membrane thicknesses between 9 and 13 nm, which results in a hydrophobic mismatch between the membrane thickness and the size of the proteins of 3.3-7.1 nm (3.5-5 times). We show that the high flexibility of PDMS, which provides membrane fluidities similar to phospholipid bilayers, is the key-factor for MP incorporation.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Itel, Fabian and Najer, Adrian and Palivan, Cornelia G and Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1530-6984
e-ISSN:1530-6992
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 Oct 2017 07:37
Deposited On:21 Apr 2016 13:58

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