Genome-wide patterns of selection in 230 ancient Eurasians

Mathieson , Iain and Lazaridis, Iosif and Rohland, Nadin and Mallick, Swapan and Patterson, Nick and Roodenberg, Songül Alpaslan and Harney, Eadaoin and Stewardson, Kristin and Fernandes, Daniel and Novak, Mario and Sirak, Kendra and Gamba, Cristina and Jones, Eppie R. and Llamas, Bastien and Dryomov, Stanislav and Pickrell, Joseph and Arsuaga, Juan Luís and de Castro, José María Bermúdez and Carbonell, Eudald and Gerritsen, Fokke and Khokhlov, Aleksandr and Kuznetsov, Pavel and Lozano, Marina and Meller, Harald and Mochalov, Oleg and Moiseyev, Vayacheslav and Guerra, Manuel A. Rojo and Roodenberg, Jacob and Vergès, Josep Maria and Krause, Johannes and Cooper, Alan and Alt, Kurt W. and Brown, Dorcas and Anthony, David and Lalueza-Fox, Carles and Haak, Wolfgang and Pinhasi, Ron and Reich, David. (2015) Genome-wide patterns of selection in 230 ancient Eurasians. Nature, 528 (7583). pp. 499-503.

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Official URL: http://edoc.unibas.ch/41889/

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Abstract

Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.

Faculties and Departments:	05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Integrative Prähistorische und Naturwissenschaftliche Archäologie (IPNA Schünemann)
UniBasel Contributors:	Alt, Kurt W.
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Macmillan
ISSN:	1476-4687
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1038/nature16152 pmid: 26595274
Last Modified:	15 Sep 2016 07:16
Deposited On:	15 Sep 2016 07:16

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