Plasmodesmata: Channels for Viruses on the Move

Heinlein, Manfred. (2015) Plasmodesmata: Channels for Viruses on the Move. In: Plasmodesmata: Methods and Protocols. New York, pp. 25-52.

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The symplastic communication network established by plasmodesmata (PD) and connected phloem provides an essential pathway for spatiotemporal intercellular signaling in plant development but is also exploited by viruses for moving their genomes between cells in order to infect plants systemically. Virus movement depends on virus-encoded movement proteins (MPs) that target PD and therefore represent important keys to the cellular mechanisms underlying the intercellular trafficking of viruses and other macromolecules. Viruses and their MPs have evolved different mechanisms for intracellular transport and interaction with PD. Some viruses move from cell to cell by interacting with cellular mechanisms that control the size exclusion limit of PD whereas other viruses alter the PD architecture through assembly of specialized transport structures within the channel. Some viruses move between cells in the form of assembled virus particles whereas other viruses may interact with nucleic acid transport mechanisms to move their genomes in a non-encapsidated form. Moreover, whereas several viruses rely on the secretory pathway to target PD, other viruses interact with the cortical endoplasmic reticulum and associated cytoskeleton to spread infection. This chapter provides an introduction into viruses and their role in studying the diverse cellular mechanisms involved in intercellular PD-mediated macromolecular trafficking.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Ehemalige Einheiten Umweltwissenschaften > Pflanzenphysiologie Pathogenabwehr (Boller)
UniBasel Contributors:Heinlein, Manfred
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:Humana Press
Series Name:Methods in molecular biology
Issue Number:1217
Note:Publication type according to Uni Basel Research Database: Book item
Identification Number:
Last Modified:18 Dec 2017 16:56
Deposited On:18 Dec 2017 16:56

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