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Developmental self-construction and -configuration of functional neocortical neuronal networks

Bauer, Roman and Zubler, Frédéric and Pfister, Sabina and Hauri, Andreas and Pfeiffer, Michael and Muir, Dylan R. and Douglas, Rodney J.. (2014) Developmental self-construction and -configuration of functional neocortical neuronal networks. PLoS Computational Biology, 10 (12). e1003994.

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Official URL: http://edoc.unibas.ch/41445/

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Abstract

The prenatal development of neural circuits must provide sufficient configuration to support at least a set of core postnatal behaviors. Although knowledge of various genetic and cellular aspects of development is accumulating rapidly, there is less systematic understanding of how these various processes play together in order to construct such functional networks. Here we make some steps toward such understanding by demonstrating through detailed simulations how a competitive co-operative ('winner-take-all', WTA) network architecture can arise by development from a single precursor cell. This precursor is granted a simplified gene regulatory network that directs cell mitosis, differentiation, migration, neurite outgrowth and synaptogenesis. Once initial axonal connection patterns are established, their synaptic weights undergo homeostatic unsupervised learning that is shaped by wave-like input patterns. We demonstrate how this autonomous genetically directed developmental sequence can give rise to self-calibrated WTA networks, and compare our simulation results with biological data.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Neural Networks (Mrsic-Flogel)
UniBasel Contributors:Muir, Dylan R
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Library of Science
ISSN:1553-734X
e-ISSN:1553-7358
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:28 Nov 2017 12:31
Deposited On:30 Aug 2016 08:09

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