Bone fractures in children with autistic spectrum disorder

Furlano, Raoul I. and Bloechliger, Marlene and Jick, Hershel and Meier, Christoph R.. (2014) Bone fractures in children with autistic spectrum disorder. Journal of developmental and behavioral pediatrics, 35 (6). pp. 353-359.

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Official URL: http://edoc.unibas.ch/41144/

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Bone fractures in children represent a source of significant disability and morbidity. Are children with autistic spectrum disorder (ASD) at an altered risk of fractures compared with typically developing children?; Using the General Practice Research Database, the authors assessed the prevalence of fractures in boys with ASD diagnosed between 2 and 8 years. A cross-sectional design was used to compare the prevalence of fractures among children with ASD and age-matched controls, conditional logistic regression to explore the relative risk of having a fracture in association with diagnosed ASD.; The study population comprised 3,219 boys with a first-time diagnosis of ASD and 12,265 matched controls. ASD was associated with a significantly decreased risk of developing a fracture at any time in childhood (odds ratio [OR], 0.68, 95% confidence interval [CI], 0.59-0.77, p < .0001). The relative risk estimates were lower for the time period after ASD diagnosis (OR, 0.56, 95% CI, 0.48-0.66, p < .0001) but were not different for the time period before ASD diagnosis (OR, 0.96, 95% CI, 0.78-1.18, p = .6866). Adjusting for use of different drugs did not change the estimates.; The relative risk of experiencing a fracture at any time in childhood is lower for boys with ASD compared with healthy boys.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Clinical Pharmacy (Meier)
UniBasel Contributors:Meier, Christoph R. and Furlano, Raoul I. and Blöchliger, Marlene
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:17 Aug 2016 09:40
Deposited On:17 Aug 2016 09:40

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