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Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders

Lester, Kathryn J. and Roberts, Susanna and Keers, Robert and Coleman, Jonathan R. I. and Breen, Gerome and Wong, Chloe C. Y. and Xu, Xiaohui and Arendt, Kristian and Blatter-Meunier, Judith and Bögels, Susan and Cooper, Peter and Creswell, Cathy and Heiervang, Einar R. and Herren, Chantal and Hogendoorn, Sanne M. and Hudson, Jennifer L. and Krause, Karen and Lyneham, Heidi J. and McKinnon, Anna and Morris, Talia and Nauta, Maaike H. and Rapee, Ronald M. and Rey, Yasmin and Schneider, Silvia and Schneider, Sophie C. and Silverman, Wendy K. and Smith, Patrick and Thastum, Mikael and Thirlwall, Kerstin and Waite, Polly and Wergeland, Gro Janne and Eley, Thalia C.. (2015) Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders. British Journal of Psychiatry, 208 (2). pp. 182-188.

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Official URL: http://edoc.unibas.ch/40798/

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Abstract

BackgroundWe previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome.AimsTo replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829).MethodLogistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed.ResultsThere was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes.ConclusionsThe association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Health & Intervention > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Blatter-Meunier, Judith
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal College of Psychiatrists
ISSN:0007-1250
e-ISSN:1472-1465
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Nov 2017 10:35
Deposited On:02 Nov 2017 10:35

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