Laser-Induced Acoustic Desorption of Natural and Functionalized Biochromophores

Sezer, Ugur and Wörner, Lisa and Horak, Johannes and Felix, Lukas and Tüxen, Jens and Götz, Christoph and Vaziri, Alipasha and Mayor, Marcel and Arndt, Markus. (2015) Laser-Induced Acoustic Desorption of Natural and Functionalized Biochromophores. Analytical Chemistry, 87 (11). pp. 5614-5619.

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Official URL: http://edoc.unibas.ch/40735/

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Laser-induced acoustic desorption (LIAD) has recently been established as a tool for analytical chemistry. It is capable of launching intact, neutral, or low charged molecules into a high vacuum environment. This makes it ideally suited to mass spectrometry. LIAD can be used with fragile biomolecules and very massive compounds alike. Here, we apply LIAD time-of-flight mass spectrometry (TOF-MS) to the natural biochromophores chlorophyll, hemin, bilirubin, and biliverdin and to high mass fluoroalkyl-functionalized porphyrins. We characterize the variation in the molecular fragmentation patterns as a function of the desorption and the VUV postionization laser intensity. We find that LIAD can produce molecular beams an order of magnitude slower than matrix-assisted laser desorption (MALD), although this depends on the substrate material. Using titanium foils we observe a most probable velocity of 20 m/s for functionalized molecules with a mass m = 10'000 Da.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Devices and Materials (Mayor)
UniBasel Contributors:Mayor, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Jun 2016 11:01
Deposited On:10 May 2016 14:42

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