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Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?

Gill, Mark E. and Erkek, Serap and Peters, Antoine H. F. M.. (2012) Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming? Current opinion in cell biology, 24 (3). pp. 387-396.

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Abstract

At fertilization, fusion of two differentiated gametes forms the zygote that is capable of forming all of the varied cell lineages of an organism. It is widely thought that the acquisition of totipotency involves extensive epigenetic reprogramming of the germline state into an embryonic state. However, recent data argue that this reprogramming is incomplete and that substantial epigenetic information passes from one generation to the next. In this review we summarize the changes in chromatin states that take place during mammalian gametogenesis and examine the evidence that early mammalian embryogenesis may be affected by inheritance of epigenetic information from the parental generation.
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI > Epigenetics > Epigenetic control of mouse germ cell and early embryonic development (Peters)
UniBasel Contributors:Peters, Antoine
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0955-0674
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:30 Jun 2016 11:01
Deposited On:29 Jan 2016 09:12

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