CTF Challenge: result summary

Marabini, Roberto and Carragher, Bridget and Chen, Shaoxia and Chen, James and Cheng, Anchi and Downing, Kenneth H. and Frank, Joachim and Grassucci, Robert A. and Heymann, J. B. and Jiang, Wen and Jonic, Slavica and Liao, Hstau Y. and Ludtke, Steven J. and Patwari, Shail and Piotrowski, Angela L. and Quintana, Adrian and Sorzano, Carlos O. S. and Stahlberg, Henning and Vargas, Javier and Voss, Neil R. and Chiu, Wah and Carazo, Jose M.. (2015) CTF Challenge: result summary. Journal of structural biology, 190 (3). pp. 348-359.

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Image formation in bright field electron microscopy can be described with the help of the contrast transfer function (CTF). In this work the authors describe the "CTF Estimation Challenge", called by the Madrid Instruct Image Processing Center (I2PC) in collaboration with the National Center for Macromolecular Imaging (NCMI) at Houston. Correcting for the effects of the CTF requires accurate knowledge of the CTF parameters, but these have often been difficult to determine. In this challenge, researchers have had the opportunity to test their ability in estimating some of the key parameters of the electron microscope CTF on a large micrograph data set produced by well-known laboratories on a wide set of experimental conditions. This work presents the first analysis of the results of the CTF Estimation Challenge, including an assessment of the performance of the different software packages under different conditions, so as to identify those areas of research where further developments would be desirable in order to achieve high-resolution structural information.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Jun 2016 11:00
Deposited On:14 Jun 2016 06:47

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