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Geographical and temporal structures of Legionella pneumophila sequence types in comunitat Valenciana (Spain), 1998 to 2013

Sánchez-Busó, Leonor and Coscollà, Mireia and Palero, Ferran and Camaró, María Luisa and Gimeno, Ana and Moreno, Pilar and Escribano, Isabel and López Perezagua, María Mar and Colomina, Javier and Vanaclocha, Herme and González-Candelas, Fernando. (2015) Geographical and temporal structures of Legionella pneumophila sequence types in comunitat Valenciana (Spain), 1998 to 2013. Applied and Environmental Microbiology, 81 (20). pp. 7106-7113.

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Official URL: http://edoc.unibas.ch/39857/

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Abstract

Legionella pneumophila is an accidental human pathogen associated with aerosol formation in water-related sources. High recombination rates make Legionella populations genetically diverse, and nearly 2,000 different sequence types (STs) have been described to date for this environmental pathogen. The spatial distribution of STs is extremely heterogeneous, with some variants being present worldwide and others being detected at only a local scale. Similarly, some STs have been associated with disease outbreaks, such as ST578 or ST23. Spain is among the European countries with the highest incidences of reported legionellosis cases, and specifically, Comunitat Valenciana (CV) is the second most affected area in the country. In this work, we aimed at studying the overall diversity of Legionella pneumophila populations found in the period from 1998 to 2013 in 79 localities encompassing 23 regions within CV. To do so, we performed sequence-based typing (SBT) on 1,088 L. pneumophila strains detected in the area from both environmental and clinical sources. A comparison with the genetic structuring detected in a global data set that included 20 European and 7 non-European countries was performed. Our results reveal a level of diversity in CV that can be considered representative of the diversity found in other countries worldwide.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Coscollá, Mireja
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
ISSN:0099-2240
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:00
Deposited On:27 Jan 2016 13:39

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