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Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery

Hussner, Janine and Begung, Robert and Boettcher, Kerstin and Gliesche, Daniel G. and Prestin, Katharina and Meyer zu Schwabedissen, Henriette E.. (2015) Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery. Vascular Pharmacology , 72. pp. 25-34.

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Official URL: http://edoc.unibas.ch/39670/

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Abstract

Clinical success of coronary drug-eluting stents (DES) is hampered by simultaneous reduction of smooth muscle cell (HCASMC) and endothelial cell proliferation due to unspecific cytotoxicity of currently used compounds. Previous in vitro data showing SMC-specific inhibition of proliferation suggested that statins may be suitable candidates for DES. It was aim of this study to further investigate statins as DES drug candidates to identify mechanisms contributing to their cell-selectivity. In vitro proliferation assays comparing the influence of various statins on HCASMC and endothelial cells confirmed that atorvastatin exhibits HCASMC-specificity. Due to similar expression levels of the drug target HMG-CoA reductase in both cell types, cellular accumulation of atorvastatin was assessed, revealing enhanced uptake in HCASMC most likely driven by significant expression of OATP2B1, a known uptake transporter for atorvastatin. In accordance with the finding that endogenous OATP2B1 influenced cellular accumulation in HCASMC we used this transporter as a tool to identify teniposide as new DES candidate drug with HCASMC-specific effects. We describe OATP2B1 as a determinant of pharmacokinetics in the coronary artery. Indeed, endogenously expressed OATP2B1 significantly influences the uptake of substrate drugs, thereby governing cell specificity. Screening of candidate drugs for interaction with OATP2B1 may be used to promote SMC-specificity.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Biopharmazie (Meyer zu Schwabedissen)
UniBasel Contributors:Meyer zu Schwabedissen, H. and Prestin, Katharina and Hussner, Janine
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1537-1891
e-ISSN:1879-3649
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:26 Oct 2017 15:53
Deposited On:23 May 2016 09:42

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