Labdane and clerodane diterpenes from Colophospermum mopane

Du, Kun and De Mieri, Maria and Neuburger, Markus and Zietsman, Pieter C. and Marston, Andrew and van Vuuren, Sandy F. and Ferreira, Daneel and Hamburger, Matthias and van der Westhuizen, Jan H.. (2015) Labdane and clerodane diterpenes from Colophospermum mopane. Journal of Natural Products, 78 (10). pp. 2494-2504.

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Official URL: http://edoc.unibas.ch/39435/

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Five labdane (1-5), an isolabdane (6), and five clerodane diterpenoids (7-11), were isolated from seeds, husks, and leaves of Colophospermum mopane. Compounds 1-3 and 6-9 are new, and their structures were elucidated by means of physical data analysis (1D and 2D NMR, HRESIMS). The absolute configurations of 1, 7, and 10 were determined by single-crystal X-ray diffraction with Cu Kα radiation. For compounds 2 and 6, the absolute configurations were established by the modified Mosher's method and corroborated by comparison of experimental and calculated electronic circular dichroism spectra of their 3-p-bromobenzoate derivatives. The crude extracts and compounds were evaluated for antimicrobial activity. The leaf extract was the most active against Staphylococcus aureus (125 μg/mL). Compound 11 showed the best inhibitory activity, with minimum inhibitory values of 15.6 μg/mL against Escherichia coli and Staphylococcus aureus and 31.3 μg/mL against Enterococcus faecalis.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias and de Mieri, Maria
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 09:33
Deposited On:04 May 2016 08:51

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