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Copper complex-assisted DNA hybridization

Bianke, Gapian and Chaurin, Valerie and Egorov, Maxim and Lebreton, Jacques and Constable, Edwin C. and Housecroft, Catherine E. and Haener, Robert. (2006) Copper complex-assisted DNA hybridization. Bioconjugate Chemistry, 17 (6). pp. 1441-1446.

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Official URL: http://edoc.unibas.ch/39168/

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Abstract

2,2`-Bipyridine ( bpy) or 1,10-phenanthroline ( phen) metal-binding domains were covalently attached to oligonucleotides, and the influence of metal ions on the hybridization of the conjugates was investigated. Metal-binding domains were attached to oligonucleotides at 3`- and 5`-terminal positions, thus placing them in juxtaposed positions after hybridization to a common target strand. While the ligands alone had a positive effect ( increased T-m) on hybrid stability, the duplex was further stabilized by the addition of copper( I) and/or copper( II) through the formation of a metal complex in which the two short sequences are linked through Cu( bpy)(2)
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Anorganische Chemie (Constable)
UniBasel Contributors:Constable, Edwin Charles
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1043-1802
e-ISSN:1520-4812
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 May 2017 08:51
Deposited On:26 Jan 2016 08:13

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