edoc

Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days) : Pierrea multi-country, prospective, non-experimental case-control study

Polman, Katja and Becker, Sören L. and Alirol, Emilie and Bhatta, Nisha K. and Bhattarai, Narayan R. and Bottieau, Emmanuel and Bratschi, Martin W. and Burza, Sakib and Coulibaly, Jean T. and Doumbia, Mama N. and Horié, Ninon S. and Jacobs, Jan and Khanal, Basudha and Landouré, Aly and Mahendradhata, Yodi and Meheus, Filip and Mertens, Pascal and Meyanti, Fransiska and Murhandarwati, Elsa H. and N'Goran, Eliézer K. and Peeling, Rosanna W. and Ravinetto, Raffaella and Rijal, Suman and Sacko, Moussa and Saye, Rénion and Schneeberger, Pierre H. H. and Schurmans, Céline and Silué, Kigbafori D. and Thobari, Jarir A. and Traoré, Mamadou S. and van Lieshout, Lisette and van Loen, Harry and Verdonck, Kristien and von Müller, Lutz and Yansouni, Cédric P. and Yao, Joel A. and Yao, Patrick K. and Yap, Peiling and Boelaert, Marleen and Chappuis, François and Utzinger, Jürg. (2015) Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days) : Pierrea multi-country, prospective, non-experimental case-control study. BMC infectious diseases, Vol. 15 , 338.

[img]
Preview
PDF - Published Version
Available under License CC BY (Attribution).

1768Kb

Official URL: http://edoc.unibas.ch/dok/A6438902

Downloads: Statistics Overview

Abstract

Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (>14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.; This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea (≥14 days; in individuals aged ≥1 year) and persistent abdominal pain (≥14 days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Côte d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies. Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected="selected" primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.; ClinicalTrials.gov; identifier: NCT02105714.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Becker, Sören Leif and Utzinger, Jürg and Yap, Peiling
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:BioMed Central
ISSN:1471-2334
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Related URLs:
Identification Number:
Last Modified:31 Dec 2015 10:59
Deposited On:06 Nov 2015 10:21

Repository Staff Only: item control page