VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation

Fantozzi, Anna and Gruber, Dorothea C. and Pisarsky, Laura and Heck, Chantal and Kunita, Akiko and Yilmaz, Mahmut and Meyer-Schaller, Nathalie and Cornille, Karen and Hopfer, Ulrike and Bentires-Alj, Mohamed and Christofori, Gerhard. (2014) VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation. Cancer research, Vol. 74, H. 5. S. 1566-1575.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6428642

Downloads: Statistics Overview


An epithelial-mesenchymal transition (EMT) underlies malignant tumor progression and metastatic spread by enabling cancer cells to depart from the primary tumor, invade surrounding tissue, and disseminate to distant organs. EMT also enriches for cancer stem cells (CSC) and increases the capacity of cancer cells to initiate and propagate tumors upon transplantation into immune-deficient mice, a major hallmark of CSCs. However, the molecular mechanisms promoting the tumorigenicity of cancer cells undergoing an EMT and of CSCs have remained widely elusive. We here report that EMT confers efficient tumorigenicity to murine breast cancer cells by the upregulated expression of the proangiogenic factor VEGF-A and by increased tumor angiogenesis. On the basis of these data, we propose a novel interpretation of the features of CSCs with EMT-induced, VEGF-A-mediated angiogenesis as the connecting mechanism between cancer cell stemness and tumor initiation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Tumor Biology (Christofori)
UniBasel Contributors:Christofori, Gerhard M.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for Cancer Research
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:02 Oct 2015 10:00
Deposited On:02 Oct 2015 10:00

Repository Staff Only: item control page