Incidence, remission and mortality of convulsive epilepsy in rural northeast South Africa

Wagner, Ryan G. and Bottomley, Christian and Ngugi, Anthony K. and Ibinda, Fredrick and Gómez-Olivé, F. Xavier and Kahn, Kathleen and Tollman, Stephen and Newton, Charles R. and Wagner, Ryan and Twine, Rhian and Connor, Myles and Collinson, Mark and Masanja, Honratio and Mathew, Alexander and Kakooza, Angelina and Pariyo, George and Peterson, Stefan and Ndyo-mughenyi, Donald and Odhiambo, Rachael and Chengo, Eddie and Chabi, Martin and Bauni, Evasius and Kamuyu, Gathoni and Odera, Victor Mung'ala and Mageto, James O. and Ae-Ngibise, Ken and Akpalu, Bright and Akpalu, Albert and Agbokey, Francis and Adjei, Patrick and Owusu-Agyei, Seth and Kleinschmidt, Immo and Doku, Victor C. K. and Odermatt, Peter and Neville, Brian and Sander, Josemir W. and White, Steve and Nutman, Thomas and Wilkins, Patricia and Noh, John. (2015) Incidence, remission and mortality of convulsive epilepsy in rural northeast South Africa. PLoS ONE, Vol. 10, H. 6 , e0129097.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6420020

Downloads: Statistics Overview


Epilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middle- income countries (LMICs). Few studies from LMICs, including much of sub-Saharan Africa, have described the incidence, remission or mortality rates due to epilepsy, which are needed to quantify the burden and inform policy. This study investigates the epidemiological parameters of convulsive epilepsy within a context of high HIV prevalence and an emerging burden of cardiovascular disease.; A cross-sectional population survey of 82,818 individuals, in the Agincourt Health and Socio-demographic Surveillance Site (HDSS) in rural northeast South Africa was conducted in 2008, from which 296 people were identified with active convulsive epilepsy. A follow-up survey was conducted in 2012. Incidence and mortality rates were estimated, with duration and remission rates calculated using the DISMOD II software package.; The crude incidence for convulsive epilepsy was 17.4/100,000 per year (95%CI: 13.1-23.0). Remission was 4.6% and 3.9% per year for males and females, respectively. The standardized mortality ratio was 2.6 (95%CI: 1.7-3.5), with 33.3% of deaths directly related to epilepsy. Mortality was higher in men than women (adjusted rate ratio (aRR) 2.6 (95%CI: 1.2-5.4)), and was significantly associated with older ages (50+ years versus those 0-5 years old (RR 4.8 (95%CI: 0.6-36.4)).; The crude incidence was lower whilst mortality rates were similar to other African studies; however, this study found higher mortality amongst older males. Efforts aimed at further understanding what causes epilepsy in older people and developing interventions to reduce prolonged seizures are likely to reduce the overall burden of ACE in rural South Africa.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Helminths and Health (Odermatt)
UniBasel Contributors:Odermatt, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:31 Aug 2018 06:39
Deposited On:02 Oct 2015 10:00

Repository Staff Only: item control page