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Air pollution from road traffic and systemic inflammation in adults : a cross-sectional analysis in the European ESCAPE project

Lanki, Timo and Hampel, Regina and Tiittanen, Pekka and Andrich, Silke and Beelen, Rob and Brunekreef, Bert and Dratva, Julia and De Faire, Ulf and Fuks, Kateryna B. and Hoffmann, Barbara and Imboden, Medea and Jousilahti, Pekka and Koenig, Wolfgang and Mahabadi, Amir A. and Künzli, Nino and Pedersen, Nancy L. and Penell, Johanna and Pershagen, Göran and Probst-Hensch, Nicole M. and Schaffner, Emmanuel and Schindler, Christian and Sugiri, Dorothea and Swart, Wim J. R. and Tsai, Ming-Yi and Turunen, Anu W. and Weinmayr, Gudrun and Wolf, Kathrin and Yli-Tuomi, Tarja and Peters, Annette. (2015) Air pollution from road traffic and systemic inflammation in adults : a cross-sectional analysis in the European ESCAPE project. Environmental Health Perspectives, 123 (8). pp. 785-791.

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Official URL: http://edoc.unibas.ch/dok/A6420012

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Abstract

Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases.; In this study we evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease.; Six cohorts of adults from Central and Northern Europe were used in this cross-sectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation-high-sensitivity C-reactive protein (CRP) and fibrinogen-were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants' long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure.; Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (< 10,000 vehicles/day) road had elevated CRP values (10.2%; 95% CI: 2.4, 18.8%, compared with persons living on a quiet residential street with > 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%; 95% CI: 0.3, 6.1 per 20 μg/m3), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed.; Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Dratva, Julia and Imboden, Medea and Künzli, Nino and Probst Hensch, Nicole and Schaffner, Emmanuel and Schindler, Christian and Tsai, Ming
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Institute of Environmental Health Sciences
ISSN:0091-6765
e-ISSN:1552-9924
Note:Publication type according to Uni Basel Research Database: Journal article -- Reproduced with permission from Environmental Health Perspectives
Language:English
Identification Number:
Last Modified:31 Aug 2017 08:42
Deposited On:02 Oct 2015 10:00

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