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The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control

Hindupur, Sravanth K. and González, Asier and Hall, Michael N.. (2015) The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control. Cold Spring Harbor Perspectives in Biology, 7 (8). pp. 1-21.

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Official URL: http://edoc.unibas.ch/dok/A6419820

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Abstract

Cell growth is a highly regulated, plastic process. Its control involves balancing positive regulation of anabolic processes with negative regulation of catabolic processes. Although target of rapamycin (TOR) is a major promoter of growth in response to nutrients and growth factors, AMP-activated protein kinase (AMPK) suppresses anabolic processes in response to energy stress. Both TOR and AMPK are conserved throughout eukaryotic evolution. Here, we review the fundamentally important roles of these two kinases in the regulation of cell growth with particular emphasis on their mutually antagonistic signaling.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cold Spring Harbor Laboratory Press
e-ISSN:1943-0264
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Dec 2017 15:58
Deposited On:02 Oct 2015 10:00

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