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Selective processing of food words during insulin-induced hypoglycemia in healthy humans

Brody, Stuart and Keller, Ulrich and Degen, Lukas and Cox, Daniel J. and Schachinger, Hartmut. (2004) Selective processing of food words during insulin-induced hypoglycemia in healthy humans. Psychopharmacology, Vol. 173, no. 1-2. pp. 217-220.

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Official URL: http://edoc.unibas.ch/dok/A6419840

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Abstract

RATIONALE: Hypoglycemia leads to undernutrition of the brain. Favoring selective processing of food stimuli would be an adaptive cognitive strategy. However, hypoglycemia is known to impair several aspects of cognitive function, and it is unknown whether selective cognitive processing of food stimuli occurs during insulin-induced hypoglycemia. METHODS: In a single-blind repeated measures design, healthy young adults (n=12, six female, mean age 28 years; mean body mass index 22.5 kg/m(2)) performed a standard Stroop word-color test, as well as a variant with food words designed to detect selective processing of food cues. Two sessions were scheduled with a 4-week interval. In each session, a hyperinsulinemic clamp method produced a normoglycemic (plasma glucose: 4.7 mmol/l) period, followed on 1 day by a hypoglycemic (2.7 mmol/l) testing period, and on the other day a second normoglycemic testing period (counterbalanced order). RESULTS: Color naming verbal reaction time (RT) increased during hypoglycemia (Ptextless0.0001). The extent of the Stroop cognitive interference was independent of plasma glucose level. The key finding is that RT for food words increased more than for non-food control words (Ptextless0.004), and this effect was not predicted by hunger ratings. CONCLUSIONS: Our data provide new evidence that during hypoglycemia, attention is directed selectively to food-relevant stimuli. The results are discussed in terms of adaptation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
UniBasel Contributors:Keller, Ulrich O.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0033-3158
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Oct 2015 10:00
Deposited On:02 Oct 2015 10:00

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