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Retrobulbar and peripheral capillary blood flow in hypercholesterolemic subjects

Senn, B. and Orgul, S. and Keller, U. and Dickermann, D. and Dubler, B. and Vavrecka, J. and Gasser, P. and Kaiser, H. J. and Flammer, J.. (1999) Retrobulbar and peripheral capillary blood flow in hypercholesterolemic subjects. American journal of ophthalmology, Vol. 128, H. 3. pp. 310-316.

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Official URL: http://edoc.unibas.ch/dok/A6419844

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Abstract

PURPOSE: To assess retrobulbar blood flow velocities and finger nailfold capillary blood flow velocities (two readily accessible vascular beds) in subjects with primary hypercholesterolemia before and during lipid-lowering therapy. METHODS: Retrobulbar blood flow velocities and finger nailfold capillary blood flow velocities were assessed in 15 hypercholesterolemic subjects and in 15 age-matched and sex-matched healthy control subjects. In addition, the change in blood flow velocities after a 3-month period of lipid-lowering therapy was evaluated. RESULTS: No alterations in retrobulbar blood flow velocities after lipid-lowering therapy could be observed in hypercholesterolemic patients. Nailfold capillary blood flow velocity was slower in hypercholesterolemic subjects than control subjects immediately after local cooling (P = .0052), but this vascular dysregulation did not improve after lipid-lowering therapy (P = .58). CONCLUSIONS: Blood flow alterations, potentially caused by perturbed vascular endothelial function, may occur in nailfold capillaries of hypercholesterolemic subjects. Such alterations were not seen in retrobulbar vessels, and blood flow measures did not change during lipid-lowering therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
UniBasel Contributors:Keller, Ulrich O.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:0002-9394
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:02 Oct 2015 10:00
Deposited On:02 Oct 2015 10:00

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