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Polymeric particulates for subunit vaccine delivery

Schuster, Thomas and Nussbaumer, Martin and Baumann, Patric and Bruns, Nico and Meier, Wolfgang and Car, Anja. (2015) Polymeric particulates for subunit vaccine delivery. In: Subunit vaccine delivery. New York, pp. 181-201.

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Official URL: http://edoc.unibas.ch/dok/A6419746

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Abstract

Vaccines still represent the best long-term treatment option for reducing many infectious diseases, including acquired immune deficiency syndrome (AIDS), malaria, and tuberculosis. Therefore, to effectively combat these severe diseases, it is of utmost importance to develop and explore novel and more efficient delivery modalities and administration routes. In this context, new polymeric nano- and microparticulate delivery platforms may represent an alternative and/or complementary therapeutic option. With the help of modern polymer chemistry, an increased number of sophisticated architectures have been developed, although these materials are in terms of bio applications still in relatively early stages. Therefore, a lot of recent attention has been dedicated to designing and tailoring novel particulates delivery systems with focus to create more efficient delivery platform. Various structures, including nanogels, nanocapsules, nano- and microparticles, dendrimers, and different hierarchical assemblies in solution have been studied in vaccine delivery. However, none of these explored platforms until now fully complies with basic delivery requirements like biocompatibility, non-toxicity, high encapsulation efficiency, and the ability to induce prolonged immune responses. In general, the unique structural and mechanical properties of polymers and their abilities to create three-dimensional structures or hybrid systems is under intensive investigation and hold a great promise in vaccine delivery.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Bruns, Nico and Schuster, Thomas and Nussbaumer, Martin and Baumann, Patric and Meier, Wolfgang P. and Car, Anja
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Bibsysno:Link to catalogue
Publisher:Springer
ISBN:978-1-4939-1416-6
e-ISBN:978-1-4939-1417-3
Note:Additional series information: Advances in Delivery Science and Technology -- Publication type according to Uni Basel Research Database: Book item
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Last Modified:13 Apr 2018 06:16
Deposited On:04 Sep 2015 14:32

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