Long-term exposure to particulate matter constituents and the incidence of coronary events in 11 European cohorts

Wolf, Kathrin and Stafoggia, Massimo and Cesaroni, Giulia and Andersen, Zorana Jovanovic and Beelen, Rob and Galassi, Claudia and Hennig, Frauke and Migliore, Enrica and Penell, Johanna and Ricceri, Fulvio and Sørensen, Mette and Turunen, Anu W. and Hampel, Regina and Hoffmann, Barbara and Kälsch, Hagen and Laatikainen, Tiina and Pershagen, Göran and Raaschou-Nielsen, Ole and Sacerdote, Carlotta and Vineis, Paolo and Badaloni, Chiara and Cyrys, Josef and de Hoogh, Kees and Eriksen, Kirsten T. and Jedynska, Aleksandra and Keuken, Menno and Kooter, Ingeborg and Lanki, Timo and Ranzi, Andrea and Sugiri, Dorothea and Tsai, Ming-Yi and Wang, Meng and Hoek, Gerard and Brunekreef, Bert and Peters, Annette and Forastiere, Francesco. (2015) Long-term exposure to particulate matter constituents and the incidence of coronary events in 11 European cohorts. Epidemiology, 26 (4). pp. 565-574.

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Official URL: http://edoc.unibas.ch/dok/A6411145

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Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.; Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM > 10 μm (PM10), PM > 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.; A 100 ng/m³ increase in PM10 K and a 50 ng/m³ increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.; This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Exposure Science (Tsai)
UniBasel Contributors:Tsai, Ming and de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2018 09:42
Deposited On:04 Sep 2015 14:30

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