The G protein-coupled receptor rhodopsin in the native membrane

Fotiadis, D. and Liang, Y. and Filipek, S. and Saperstein, D. A. and Engel, A. and Palczewski, K.. (2004) The G protein-coupled receptor rhodopsin in the native membrane. FEBS letters, Vol. 564, H. 3. pp. 281-288.

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Official URL: http://edoc.unibas.ch/dok/A5262406

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The higher-order structure of G protein-coupled receptors (GPCRs) in membranes may involve dimerization and formation of even larger oligomeric complexes. Here, we have investigated the organization of the prototypical GPCR rhodopsin in its native membrane by electron and atomic force microscopy (AFM). Disc membranes from mice were isolated and observed by AFM at room temperature. In all experimental conditions, rhodopsin forms structural dimers organized in paracrystalline arrays. A semi-empirical molecular model for the rhodopsin paracrystal is presented validating our previously reported results. Finally, we compare our model with other currently available models describing the supramolecular structure of GPCRs in the membrane.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
UniBasel Contributors:Engel, Andreas H
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Aug 2015 12:05
Deposited On:22 Mar 2012 13:23

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