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Air pollution and atherosclerosis : a cross-sectional analysis of four European cohort studies in the ESCAPE study

Perez, Laura and Wolf, Kathrin and Hennig, Frauke and Penell, Johanna and Basagaña, Xavier and Foraster, Maria and Aguilera, Inmaculada and Agis, David and Beelen, Rob and Brunekreef, Bert and Cyrys, Josef and Fuks, Kateryna B. and Adam, Martin and Baldassarre, Damiano and Cirach, Marta and Elosua, Roberto and Dratva, Julia and Hampel, Regina and Koenig, Wolfgang and Marrugat, Jaume and de Faire, Ulf and Pershagen, Göran and Probst-Hensch, Nicole M. and de Nazelle, Audrey and Nieuwenhuijsen, Mark J. and Rathmann, Wolfgang and Rivera, Marcela and Seissler, Jochen and Schindler, Christian and Thiery, Joachim and Hoffmann, Barbara and Peters, Annette and Künzli, Nino. (2015) Air pollution and atherosclerosis : a cross-sectional analysis of four European cohort studies in the ESCAPE study. Environmental Health Perspectives, 123 (6). pp. 597-605.

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Official URL: http://edoc.unibas.ch/dok/A6391006

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Abstract

In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a preclinical marker of atherosclerosis.; Individually assigned levels of nitrogen dioxide, nitrogen oxides, particulate matter ≤ 2.5 μm (PM2.5), absorbance of PM2.5 (PM2.5abs), PM10, PMcoarse, and two indicators of residential proximity to highly trafficked roads were obtained under a standard exposure protocol (European Study of Cohorts for Air Pollution Effects-ESCAPE study) in the Stockholm area (Sweden), the Ausburg and Ruhr area (Germany), and the Girona area (Spain). We used linear regression and meta-analyses to examine the association between long-term exposure to air pollution and CIMT.; The meta-analysis with 9,183 individuals resulted in an estimated increase in CIMT (geometric mean) of 0.72% (95% CI: -0.65%, 2.10%) per 5-μg/m3 increase in PM2.5 and 0.42% (95% CI: -0.46%, 1.30%) per 10-5/m increase in PM2.5abs. Living in proximity to high traffic was also positively but not significantly associated with CIMT. Meta-analytic estimates for other pollutants were inconsistent. Results were similar across different adjustment sets and sensitivity analyses. In an extended meta-analysis for PM2.5 with three other previously published studies, a 0.78% (95% CI: -0.18%, 1.75%) increase in CIMT was estimated for a 5-μg/m3 contrast in PM2.5.; Using a standardized exposure and analytical protocol in four European cohorts, we found that cross-sectional associations between CIMT and the eight ESCAPE markers of long-term residential air pollution exposure did not reach statistical significance. The additional meta-analysis of CIMT and PM2.5 across all published studies also was positive but not significant.;
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Adam, Martin and Dratva, Julia and Probst Hensch, Nicole and Schindler, Christian and Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Institute of Environmental Health Sciences
ISSN:0091-6765
e-ISSN:1552-9924
Note:Publication type according to Uni Basel Research Database: Journal article -- Reproduced with permission from Environmental Health Perspectives
Language:English
Identification Number:
Last Modified:31 Aug 2017 08:46
Deposited On:03 Jul 2015 08:53

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