edoc

Maturation and mip-1β production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults : impact by HIV and Mycobacterium tuberculosis co-infections

Portevin, Damien and Moukambi, Félicien and Mpina, Maxmillian and Bauer, Asli and Haraka, Frederick and Chachage, Mkunde and Metzger, Philipp and Saathoff, Elmar and Clowes, Petra and Ntinginya, Nyanda E. and Rachow, Andrea and Hoelscher, Michael and Reither, Klaus and Daubenberger, Claudia A. and Geldmacher, Christof. (2015) Maturation and mip-1β production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults : impact by HIV and Mycobacterium tuberculosis co-infections. PLoS ONE, Vol. 10, H. 5 , e0126716.

[img]
Preview
PDF - Published Version
Available under License CC BY (Attribution).

2110Kb

Official URL: http://edoc.unibas.ch/dok/A6381866

Downloads: Statistics Overview

Abstract

It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1β and the T cell maturation marker CD27 within CMVpp65-specific CD4+ and CD8+ T cells in relation to age, HIV and active Tuberculosis (TB) co-infection in a cohort of Tanzanian volunteers (≤16 years of age, n = 108 and ≥18 years, n = 79). Independent of HIV co-infection, IFNγ+ CMVpp65-specific CD4+ T cell frequencies increased with age. In adults, HIV co-infection further increased the frequencies of these cells. A high capacity for Mip-1β production together with a CD27low phenotype was characteristic for these cells in children and adults. Interestingly, in addition to HIV co-infection active TB disease was linked to further down regulation of CD27 and increased capacity of Mip-1β production in CMVpp65-specific CD4+ T cells. These phenotypic and functional changes of CMVpp65-specific CD4 T cells observed during HIV infection and active TB could be associated with increased CMV reactivation rates.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Clinical Immunology (Daubenberger)
UniBasel Contributors:Portevin, Damien and Daubenberger, Claudia and Reither, Klaus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Related URLs:
Identification Number:
Last Modified:31 Aug 2018 06:38
Deposited On:05 Jun 2015 08:53

Repository Staff Only: item control page