Molecular analysis of gene expression in the developing pontocerebellar projection system

Diaz, E. and Ge, Y. and Yang, Y. H. and Loh, K. C. and Serafini, T. A. and Okazaki, Y. and Hayashizaki, Y. and Speed, T. P. and Ngai, J. and Scheiffele, P.. (2002) Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron, Vol. 36, H. 3. pp. 417-434.

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Official URL: http://edoc.unibas.ch/dok/A5259861

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As an approach toward understanding the molecular mechanisms of neuronal differentiation, we utilized DNA microarrays to elucidate global patterns of gene expression during pontocerebellar development. Through this analysis, we identified groups of genes specific to neuronal precursor cells, associated with axon outgrowth, and regulated in response to contact with synaptic target cells. In the cerebellum, we identified a phase of granule cell differentiation that is independent of interactions with other cerebellar cell types. Analysis of pontine gene expression revealed that distinct programs of gene expression, correlated with axon outgrowth and synapse formation, can be decoupled and are likely influenced by different cells in the cerebellar target environment. Our approach provides insight into the genetic programs underlying the differentiation of specific cell types in the pontocerebellar projection system.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Scheiffele)
UniBasel Contributors:Scheiffele, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Nov 2017 10:54
Deposited On:22 Mar 2012 13:23

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