Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans

Hysek, C. and Schmid, Y. and Rickli, A. and Simmler, L. D. and Donzelli, M. and Grouzmann, E. and Liechti, M. E.. (2012) Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans. British journal of pharmacology, Vol. 166, H. 8. pp. 2277-2288.

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Official URL: http://edoc.unibas.ch/dok/A6338341

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BACKGROUND AND PURPOSE: The use of +/- 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') is associated with cardiovascular complications and hyperthermia. EXPERIMENTAL APPROACH: We assessed the effects of the alpha(1) - and beta-adrenoceptor antagonist carvedilol on the cardiostimulant, thermogenic and subjective responses to MDMA in 16 healthy subjects. Carvedilol (50 mg) or placebo was administered 1 h before MDMA (125 mg) or placebo using a randomized, double-blind, placebo-controlled, four-period crossover design. KEY RESULTS Carvedilol reduced MDMA-induced elevations in blood pressure, heart rate and body temperature. Carvedilol did not affect the subjective effects of MDMA including MDMA-induced good drug effects, drug high, drug liking, stimulation or adverse effects. Carvedilol did not alter the plasma exposure to MDMA. CONCLUSIONS AND IMPLICATIONS: alpha(1) - and beta-Adrenoceptors contribute to the cardiostimulant and thermogenic effects of MDMA in humans but not to its psychotropic effects. Carvedilol could be useful in the treatment of cardiovascular and hyperthermic complications associated with ecstasy use.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Psychopharmacology Research (Liechti)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Neuropharmacology (Simmler)
UniBasel Contributors:Liechti, Matthias Emanuel and Simmler, Linda
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Apr 2023 03:10
Deposited On:08 May 2015 08:45

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