Inferring epidemic contact structure from phylogenetic trees

Leventhal, G. E. and Kouyos, R. and Stadler, T. and von Wyl, V. and Yerly, S. and Boni, J. and Cellerai, C. and Klimkait, T. and Gunthard, H. F. and Bonhoeffer, S.. (2012) Inferring epidemic contact structure from phylogenetic trees. PLoS Computational Biology, Vol. 8, H. 3 , e1002413.

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Official URL: http://edoc.unibas.ch/dok/A6338395

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Contact structure is believed to have a large impact on epidemic spreading and consequently using networks to model such contact structure continues to gain interest in epidemiology. However, detailed knowledge of the exact contact structure underlying real epidemics is limited. Here we address the question whether the structure of the contact network leaves a detectable genetic fingerprint in the pathogen population. To this end we compare phylogenies generated by disease outbreaks in simulated populations with different types of contact networks. We find that the shape of these phylogenies strongly depends on contact structure. In particular, measures of tree imbalance allow us to quantify to what extent the contact structure underlying an epidemic deviates from a null model contact network and illustrate this in the case of random mixing. Using a phylogeny from the Swiss HIV epidemic, we show that this epidemic has a significantly more unbalanced tree than would be expected from random mixing.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait)
UniBasel Contributors:Klimkait, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Library of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Oct 2017 10:13
Deposited On:08 May 2015 08:45

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