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Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal ganglia

Held, K. and Eiglmeier, I. and Himmelein, S. and Sinicina, I. and Brandt, T. and Theil, D. and Dornmair, K. and Derfuss, T.. (2012) Clonal expansions of CD8(+) T cells in latently HSV-1-infected human trigeminal ganglia. Journal of neurovirology, Vol. 18, H. 1. pp. 62-68.

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Official URL: http://edoc.unibas.ch/dok/A6338634

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Abstract

Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor beta-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded beta-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
UniBasel Contributors:Derfuss, Tobias Johannes
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Taylor & Francis
ISSN:1538-2443
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 May 2015 08:45
Deposited On:08 May 2015 08:45

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