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mTOR signaling in cellular and organismal energetics

Albert, V. and Hall, M. N.. (2014) mTOR signaling in cellular and organismal energetics. Current Opinion in Cell Biology, Vol. 33. pp. 55-66.

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Official URL: http://edoc.unibas.ch/dok/A6337742

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Abstract

Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0955-0674
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:09 Nov 2017 10:18
Deposited On:08 May 2015 08:44

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