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A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C

Lange, C. M. and Bibert, S. and Kutalik, Z. and Burgisser, P. and Cerny, A. and Dufour, J. F. and Geier, A. and Gerlach, T. J. and Heim, M. H. and Malinverni, R. and Negro, F. and Regenass, S. and Badenhoop, K. and Bojunga, J. and Sarrazin, C. and Zeuzem, S. and Muller, T. and Berg, T. and Bochud, P. Y. and Moradpour, D.. (2012) A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C. PLoS ONE, Vol. 7, H. 7 , e40159.

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Official URL: http://edoc.unibas.ch/dok/A6338537

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Abstract

BACKGROUND: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-alpha-based therapy of chronic hepatitis C. METHODOLOGY/PRINCIPAL FINDINGS: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1alpha-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-alpha (PEG-IFN-alpha) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D(3) (25[OH]D(3)) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061-2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D(3)>20 ng/mL) during all seasons, but 25(OH)D(3) serum levels were not associated with treatment outcome. CONCLUSIONS/SIGNIFICANCE: Our study suggests a role of bioactive vitamin D (1,25[OH](2)D(3), calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D(3) is not a suitable predictor of treatment outcome.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)
UniBasel Contributors:Heim, Markus H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2018 06:39
Deposited On:08 May 2015 08:44

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