Helicobacter pylori vaccine development based on combined subproteome analysis

Bumann, D. and Jungblut, P. R. and Meyer, T. F.. (2004) Helicobacter pylori vaccine development based on combined subproteome analysis. Proteomics, 4 (10). pp. 2843-2848.

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Official URL: http://edoc.unibas.ch/dok/A5259811

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Effective vaccines could provide long-term solutions to many important infectious diseases, however, vaccine development has been hampered by the slow identification of protective antigens. Proteomics provides global information about relevant antigen properties and thus might be ideally suited for identifying promising vaccine antigen subsets. Helicobacter pylori proteomics data are stored in a proteomics database (http://www.mpiib-berlin.mpg.de/2D-PAGE/). In this review, we describe how a combined Helicobacter subproteome analysis resulted in the rapid identification of novel, highly protective antigens. This illustrates the great potential of pathogen proteomics for vaccine development.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Nov 2017 09:43
Deposited On:22 Mar 2012 13:23

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