25 years of interferon-based treatment of chronic hepatitis C : an epoch coming to an end

Heim, M. H.. (2013) 25 years of interferon-based treatment of chronic hepatitis C : an epoch coming to an end. Nature reviews. Immunology, Vol. 13, H. 7. pp. 535-542.

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Official URL: http://edoc.unibas.ch/dok/A6338533

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Chronic hepatitis caused by infection with hepatitis C virus C (HCV) (therefore known as chronic hepatitis C (CHC)) is a leading cause of liver disease worldwide. For the past 25 years, recombinant interferon-alpha (IFNalpha) has been the main component of treatments for HCV infection. Treatment efficacy has shown a stepwise improvement following the pegylation of IFNalpha and its use in combination with other antiviral drugs. However, viral escape mechanisms, refractory IFNalpha signalling in the liver and substantial drug toxicity still limit the efficacy of this treatment. A new generation of HCV-specific antiviral drugs will probably improve response rates and might replace IFNs in CHC treatment in the next few years. This Timeline article summarizes the history of CHC treatment using recombinant IFNalpha with an emphasis on the mechanisms of action and the causes of non-response.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)
UniBasel Contributors:Heim, Markus H.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:14
Deposited On:10 Apr 2015 09:14

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