Pregnancy and reproduction in autoimmune rheumatic diseases

Ostensen, M. and Brucato, A. and Carp, H. and Chambers, C. and Dolhain, R. J. and Doria, A. and Forger, F. and Gordon, C. and Hahn, S. and Khamashta, M. and Lockshin, M. D. and Matucci-Cerinic, M. and Meroni, P. and Nelson, J. L. and Parke, A. and Petri, M. and Raio, L. and Ruiz-Irastorza, G. and Silva, C. A. and Tincani, A. and Villiger, P. M. and Wunder, D. and Cutolo, M.. (2011) Pregnancy and reproduction in autoimmune rheumatic diseases. Rheumatology, Vol. 50, no. 4. pp. 657-664.

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Official URL: http://edoc.unibas.ch/dok/A6338570

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Despite evidence for the important role of oestrogens in the aetiology and pathophysiology of chronic immune/inflammatory diseases, the previous view of an unequivocal beneficial effect of oestrogens on RA compared with a detrimental effect on SLE has to be reconsidered. Likewise, the long-held belief that RA remits in the majority of pregnant patients has been challenged, and shows that only half of the patients experience significant improvement when objective disease activity measurements are applied. Pregnancies in patients with SLE are mostly successful when well planned and monitored interdisciplinarily, whereas a small proportion of women with APS still have adverse pregnancy outcomes in spite of the standard treatment. New prospective studies indicate better outcomes for pregnancies in women with rare diseases such as SSc and vasculitis. Fertility problems are not uncommon in patients with rheumatic disease and need to be considered in both genders. Necessary therapy, shortly before or during the pregnancy, demands taking into account the health of both mother and fetus. Long-term effects of drugs on offspring exposed in utero or during lactation is a new area under study as well as late effects of maternal rheumatic disease on children.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Prenatal Medicine (Hahn)
UniBasel Contributors:Hahn, Sinuhe
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Univ. Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:10 Apr 2015 09:13

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