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Fine tuning by human CD1e of lipid-specific immune responses

Facciotti, F. and Cavallari, M. and Angenieux, C. and Garcia-Alles, L. F. and Signorino-Gelo, F. and Angman, L. and Gilleron, M. and Prandi, J. and Puzo, G. and Panza, L. and Xia, C. and Wang, P. G. and Dellabona, P. and Casorati, G. and Porcelli, S. A. and de la Salle, H. and Mori, L. and De Libero, G.. (2011) Fine tuning by human CD1e of lipid-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 34. pp. 14228-14233.

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Official URL: http://edoc.unibas.ch/dok/A6338654

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Abstract

CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero)
UniBasel Contributors:De Libero, Gennaro
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:National Academy of Sciences
ISSN:0027-8424
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:10 Apr 2015 09:13

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