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Lipidomic "deep profiling" : an enhanced workflow to reveal new molecular species of signaling lipids

Narayanaswamy, Pradeep and Shinde, Sudhirkumar and Sulc, Robert and Kraut, Rachel and Staples, Gregory and Thiam, Chung Hwee and Grimm, Rudolf and Sellergren, Börje and Torta, Federico and Wenk, Markus R.. (2014) Lipidomic "deep profiling" : an enhanced workflow to reveal new molecular species of signaling lipids. Analytical chemistry, Vol. 86, H. 6. pp. 3043-3047.

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Official URL: http://edoc.unibas.ch/dok/A6348510

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Abstract

Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of lipid classes. We introduce a strategy to capture phospho-monoester lipids and improve the detection of long-chain base phosphates (LCB-Ps, e.g., sphingosine-1-phosphate). Ten novel LCB-Ps (d18:2, t20:1, odd carbon forms) were discovered and characterized in tissues from human and mouse, as well in D. melanogaster and S. cerevisiae. These findings have immediate relevance for our understanding of sphingosine-1-phosphate biosynthesis, signaling, and degradation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Wenk, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:0003-2700
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:12
Deposited On:10 Apr 2015 09:12

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