Heterogeneous Host-Pathogen Encounters: Act Locally, Think Globally

Bumann, Dirk. (2015) Heterogeneous Host-Pathogen Encounters: Act Locally, Think Globally. Cell Host & Microbe, 17 (1). pp. 13-19.

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Official URL: http://edoc.unibas.ch/dok/A6348289

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Recent studies are revealing astonishing heterogeneity in host-pathogen interactions occurring simultaneously within the same host tissue. As highlighted in this review, growing knowledge of the in vivo complexity is altering our understanding of infection biology. In particular, pathogen subsets reside in diverse tissue microenvironments and detect and respond to local conditions. The individual pathogen-host encounters have disparate outcomes, depending on differential molecular interactions. As a result, disease progression can result from failure to control individual infection foci, despite successful eradication of others, and antibiotic therapy can be delayed by distinct pre-existing pathogen subsets. Together, these data are unraveling rich biology with implications for infectious disease progression and control.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:27 Nov 2017 09:48
Deposited On:10 Apr 2015 09:12

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