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A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

Lepore, Marco and de Lalla, Claudia and Gundimeda, S. Ramanjaneyulu and Gsellinger, Heiko and Consonni, Michela and Garavaglia, Claudio and Sansano, Sebastiano and Piccolo, Francesco and Scelfo, Andrea and Häussinger, Daniel and Montagna, Daniela and Locatelli, Franco and Bonini, Chiara and Bondanza, Attilio and Forcina, Alessandra and Li, Zhiyuan and Ni, Guanghui and Ciceri, Fabio and Jenö, Paul and Xia, Chengfeng and Mori, Lucia and Dellabona, Paolo and Casorati, Giulia and De Libero, Gennaro. (2014) A novel self-lipid antigen targets human T cells against CD1c(+) leukemias. Journal of Experimental Medicine, 211 (7). pp. 1363-1377.

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Official URL: http://edoc.unibas.ch/dok/A6348326

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Abstract

T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immunodeficient mice against CD1c(+) human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Nuclear Magnetic Resonance (Häussinger)
UniBasel Contributors:De Libero, Gennaro and Häussinger, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Rockefeller University Press
ISSN:0022-1007
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:29 Mar 2017 14:10
Deposited On:10 Apr 2015 09:12

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