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Molecular diversity subdivides the adult forebrain neural stem cell population

Giachino, C. and Basak, O. and Lugert, S. and Knuckles, P. and Obernier, K. and Fiorelli, R. and Frank, S. and Raineteau, O. and Alvarez-Buylla, A. and Taylor, V.. (2013) Molecular diversity subdivides the adult forebrain neural stem cell population. Stem cells, Vol. 32, H. 1. pp. 70-84.

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Official URL: http://edoc.unibas.ch/dok/A6338054

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Abstract

Neural stem cells (NSCs) in the ventricular domain of the subventricular zone (V-SVZ) of rodents produce neurons throughout life while those in humans become largely inactive or may be lost during infancy. Most adult NSCs are quiescent, express glial markers and depend on Notch signaling for their self-renewal and the generation of neurons. Using genetic markers and lineage tracing we identified subpopulations of adult V-SVZ NSCs (Type1, 2 and 3) indicating a striking heterogeneity including activated, brain lipid binding protein (BLBP, FABP7) expressing stem cells. BLBP+ NSCs are mitotically active components of pinwheel structures in the lateral ventricle walls and persistently generate neurons in adulthood. BLBP+ NSCs express epidermal growth factor (EGF) receptor, proliferate in response to EGF and are a major clonogenic population in the SVZ. We also find BLBP expressed by proliferative ventricular and subventricular progenitors in the fetal and postnatal human brain. Loss of BLBP+ stem/progenitor cells correlates with reduced neurogenesis in aging rodents and postnatal humans. These findings of molecular heterogeneity and proliferative differences subdivide the NSC population and have implications for neurogenesis in the forebrain of mammals during aging. Stem Cells 2013.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Embryology and Stem Cell Biology (Taylor)
UniBasel Contributors:Taylor, Verdon
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:AlphaMed Press
ISSN:1066-5099
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Mar 2015 07:44
Deposited On:06 Mar 2015 07:44

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