Recent Achievments in the Design and Engineering of Artificial Metalloenzymes

Dürrenberger, Marc and Ward, Thomas R.. (2014) Recent Achievments in the Design and Engineering of Artificial Metalloenzymes. Current Opinion in Chemical Biology, 19. pp. 99-106.

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Official URL: http://edoc.unibas.ch/dok/A6338945

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Herein, we highlight a selection of recent successes in the creation of artificial metalloenzymes. A particular emphasis is set on different anchoring methods to incorporate the abiotic metal cofactor within the host protein as well as promising strategies for the de novo design of artificial metalloenzymes. Both approaches yield promiscuous catalytic activities which expand the catalytic repertoire of biocatalysis and synthetic biology. Moreover, we summarize laboratory evolution protocols which have contributed to unravel the full potential of artificial metalloenzymes.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Dürrenberger, Marc and Ward, Thomas R.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 May 2017 07:06
Deposited On:06 Mar 2015 07:44

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