Recent Trends in Biomimetic NADH Regeneration

Quinto, Tommaso and Köhler, Valentin and Ward, Thomas R.. (2014) Recent Trends in Biomimetic NADH Regeneration. Topics in catalysis, 57 (5). p. 321.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6338943

Downloads: Statistics Overview


Nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate constitute a major cost factor in preparative biotransformations. The development of efficient methods for their regeneration with cheap reducing equivalents has been an area of intense research in the last decades. Methods explored include chemical, electrochemical, and photochemical approaches. None of the methods to regenerate NADH has reached an efficiency comparable with enzymatic regeneration (e.g. formate dehydrogenase) which remains the method of choice for most applications. In this review, we summarize primarily organometallic-based approaches for NADH regeneration methods which include non-enzymatic steps, before moving on to the most recent developments in synthetic NADH related transformations. We highlight the frequent problem of mutual inactivation between the organometallic catalyst for NADH regeneration and the corresponding NADH dependent downstream enzyme. Potential remedies are discussed, such as the compartmentalization of the organometallic complex.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Quinto, Tommaso and Köhler, Valentin and Ward, Thomas R.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 May 2017 07:09
Deposited On:06 Feb 2015 09:59

Repository Staff Only: item control page