Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

von Burg, Nicole and Chappaz, Stéphane and Baerenwaldt, Anne and Horvath, Edit and Bose Dasgupta, Somdeb and Ashok, Devika and Pieters, Jean and Tacchini-Cottier, Fabienne and Rolink, Antonius and Acha-Orbea, Hans and Finke, Daniela. (2014) Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proceedings of the National Academy of Sciences, 111 (35). pp. 12835-12840.

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Official URL: http://edoc.unibas.ch/dok/A6328797

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Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokines, up-regulate surface MHC class II molecules, and express costimulatory molecules. ILC3s can take up latex beads, process protein antigen, and consequently prime CD4(+) T-cell responses in vitro. The cognate interaction of ILC3s and CD4(+) T cells leads to T-cell proliferation both in vitro and in vivo, whereas its disruption impairs specific T-cell and T-dependent B-cell responses in vivo. In addition, the ILC3-CD4(+) T-cell interaction is bidirectional and leads to the activation of ILC3s. Taken together, our data reveal a novel activation-dependent function of peripheral ILC3s in eliciting cognate CD4(+) T-cell immune responses.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean and Finke, Daniela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Oct 2017 07:02
Deposited On:06 Feb 2015 09:58

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