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Long-term exposure to ambient air pollution and incidence of cerebrovascular events : results from 11 European cohorts within the ESCAPE project

Stafoggia, Massimo and Cesaroni, Giulia and Peters, Annette and Andersen, Zorana J. and Badaloni, Chiara and Beelen, Rob and Caracciolo, Barbara and Cyrys, Josef and de Faire, Ulf and de Hoogh, Kees and Eriksen, Kirsten T. and Fratiglioni, Laura and Galassi, Claudia and Gigante, Bruna and Havulinna, Aki S. and Hennig, Frauke and Hilding, Agneta and Hoek, Gerard and Hoffmann, Barbara and Houthuijs, Danny and Korek, Michal and Lanki, Timo and Leander, Karin and Magnusson, Patrik K. and Meisinger, Christa and Migliore, Enrica and Overvad, Kim and Ostenson, Claes-Göran and Pedersen, Nancy L. and Pekkanen, Juha and Penell, Johanna and Pershagen, Goran and Pundt, Noreen and Pyko, Andrei and Raaschou-Nielsen, Ole and Ranzi, Andrea and Ricceri, Fulvio and Sacerdote, Carlotta and Swart, Wim J. R. and Turunen, Anu W. and Vineis, Paolo and Weimar, Christian and Weinmayr, Gudrun and Wolf, Kathrin and Brunekreef, Bert and Forastiere, Francesco. (2014) Long-term exposure to ambient air pollution and incidence of cerebrovascular events : results from 11 European cohorts within the ESCAPE project. Environmental Health Perspectives, 122 (9). pp. 919-925.

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Abstract

Few studies have investigated effects of air pollution on the incidence of cerebrovascular events.; We assessed the association between long-term exposure to multiple air pollutants and the incidence of stroke in European cohorts.; Data from 11 cohorts were collected, and occurrence of a first stroke was evaluated. Individual air pollution exposures were predicted from land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE). The exposures were: PM2.5 [particulate matter (PM) ≤ 2.5 μm in diameter], coarse PM (PM between 2.5 and 10 μm), PM10 (PM ≤ 10 μm), PM2.5 absorbance, nitrogen oxides, and two traffic indicators. Cohort-specific analyses were conducted using Cox proportional hazards models. Random-effects meta-analysis was used for pooled effect estimation.; A total of 99,446 study participants were included, 3,086 of whom developed stroke. A 5-μg/m3 increase in annual PM2.5 exposure was associated with 19% increased risk of incident stroke [hazard ratio (HR) = 1.19, 95% CI: 0.88, 1.62]. Similar findings were obtained for PM10. The results were robust to adjustment for an extensive list of cardiovascular risk factors and noise coexposure. The association with PM2.5 was apparent among those ≥ 60 years of age (HR = 1.40, 95% CI: 1.05, 1.87), among never-smokers (HR = 1.74, 95% CI: 1.06, 2.88), and among participants with PM2.5 exposure > 25 μg/m3 (HR = 1.33, 95% CI: 1.01, 1.77).; We found suggestive evidence of an association between fine particles and incidence of cerebrovascular events in Europe, even at lower concentrations than set by the current air quality limit value.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Institute of Environmental Health Sciences
ISSN:0091-6765
e-ISSN:1552-9924
Note:Publication type according to Uni Basel Research Database: Journal article -- Reproduced with permission from Environmental Health Perspectives
Language:English
Identification Number:
Last Modified:31 Aug 2017 09:06
Deposited On:09 Jan 2015 09:25

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