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pH-Responsive PDMS-b-PDMAEMA Micelles for Intracellular Anticancer Drug Delivery

Car*, A. and Baumann, P. and Duskey, J. and Chami, M. and Bruns, N. and Meier*, W.. (2014) pH-Responsive PDMS-b-PDMAEMA Micelles for Intracellular Anticancer Drug Delivery. Biomacromolecules, 15 (9). pp. 3235-3245.

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Official URL: http://edoc.unibas.ch/dok/A6329061

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Abstract

A series of poly(dimethysiloxane)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMS-b-PDMAEMA) block copolymers were synthesized with atom transfer radical polymerization (ATRP). In aqueous solution the polymers self-assembled into micelles with diameters between 80 and 300 nm, with the ability to encapsulate DOX. The polymer with the shortest PDMAEMA block (5 units) displayed excellent cell viability, while micelles containing longer PDMAEMA block lengths (13 and 22 units) led to increased cytotoxicity. The carriers released DOX in response to a decrease in pH from 7.4 to 5.5. Confocal laser scanning microscopy (CLSM) revealed that nanoparticles were taken up by endocytosis into acidic cell compartments. Furthermore, DOX-loaded nanocarriers exhibited intracellular pH-response as changes in cell morphology and drug release were observed within 24 h.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P. and Chami, Mohamed and Bruns, Nico and Baumann, Patric and Car, Anja and Duskey, Jason Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:1525-7797
e-ISSN:1526-4602
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:04 Jun 2018 12:11
Deposited On:09 Jan 2015 09:25

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