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Identification of protective antigens for vaccination against systemic salmonellosis

Bumann, Dirk. (2014) Identification of protective antigens for vaccination against systemic salmonellosis. Frontiers in Immunology, 5 (381). pp. 1-5.

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Official URL: http://edoc.unibas.ch/dok/A6308409

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Abstract

There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a challenging task. Here, I review crucial properties of Salmonella antigens that might help to narrow down the number of potential candidates from more than 4000 proteins encoded in Salmonella genomes, to a more manageable number of 50-200 most promising antigens. I also discuss complementary approaches for antigen identification and potential limitations of current pre-clinical vaccine testing.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Frontiers Media
e-ISSN:1664-3224
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:22 Nov 2017 09:07
Deposited On:07 Nov 2014 08:29

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