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Reproducibility of functional connectivity and graph measures based on the Phase Lag Index (PLI) and weighted Phase Lag Index (wPLI) derived from high resolution EEG

Hardmeier, Martin and Hatz, Florian and Bousleiman, Habib and Schindler, Christian and Stam, Cornelis Jan and Fuhr, Peter. (2014) Reproducibility of functional connectivity and graph measures based on the Phase Lag Index (PLI) and weighted Phase Lag Index (wPLI) derived from high resolution EEG. PLoS ONE, Vol. 9, H. 10 , e108648.

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Official URL: http://edoc.unibas.ch/dok/A6308501

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Abstract

Functional connectivity (FC) and graph measures provide powerful means to analyze complex networks. The current study determines the inter-subject-variability using the coefficient of variation (CoV) and long-term test-retest-reliability (TRT) using the intra-class correlation coefficient (ICC) in 44 healthy subjects with 35 having a follow-up at years 1 and 2. FC was estimated from 256-channel-EEG by the phase-lag-index (PLI) and weighted PLI (wPLI) during an eyes-closed resting state condition. PLI quantifies the asymmetry of the distribution of instantaneous phase differences of two time-series and signifies, whether a consistent non-zero phase lag exists. WPLI extends the PLI by additionally accounting for the magnitude of the phase difference. Signal-space global and regional PLI/wPLI and weighted first-order graph measures, i.e. normalized clustering coefficient (gamma), normalized average path length (lambda), and the small-world-index (SWI) were calculated for theta-, alpha1-, alpha2- and beta-frequency bands. Inter-subject variability of global PLI was low to moderate over frequency bands (0.12
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics - Frequency Modelling (Schindler)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Schindler, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Language:German
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Last Modified:31 Aug 2018 06:39
Deposited On:07 Nov 2014 08:28

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