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Is there a differential impact of parity on blood pressure by age?

Dratva, Julia and Schneider, Cornelia and Schindler, Christian and Stolz, Daiana and Gerbase, Margaret and Pons, Marco and Bettschart, Robert and Gaspoz, Jean-Michel and Künzli, Nino and Zemp, Elisabeth and Probst-Hensch, Nicole. (2014) Is there a differential impact of parity on blood pressure by age? Journal of hypertension, 32 (11). pp. 2146-2151.

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Official URL: http://edoc.unibas.ch/dok/A6308500

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Abstract

In pregnancy, women experience metabolic and hemodynamic changes of potential long-term impact. Conflicting evidence exists on the impact on blood pressure (BP). We investigated the association between parity and BP in the Swiss Study on Air Pollution And Lung and Heart Disease In Adults cohort.; Multilevel linear and logistic regression analyses were performed in 2837 women aged 30-73 years, with data on parity, number of births, BP, and doctor-diagnosed hypertension adjusting for potential confounders. Hypertension was defined as at least 140/90 mmHg, doctor diagnosed or taking relevant treatment. Stratified analyses were performed by age (>40, 40-59, and ≥60 years) and menopausal status.; Parous women had a mean of 2.3 pregnancies (SD 0.95, range 1-7). A total of 26% were nulliparous. Mean BP was 119/76 mmHg in nulliparous and 121/76 mmHg in parous women. Parity had a significant adverse effect on BP in women at least 60 years [SBP 5.6 mmHg, 95% confidence interval (CI) 2.3 to 8.9; DBP 1.8 mmHg, 95% CI 0.1 to 3.6] and protective effect in women below 40 years (SBP -3.4 mmHg, 95% CI -5.8 to -1.0; DBP -0.2 mmHg, 95% CI -1.0 to 0.6). With increasing number of births, SBP (mmHg/birth; 95% CI) increased in older (1.2, 95% CI 0.2 to 2.2) and decreased in younger women (-1.6, 95% CI -2.6 to -0.5). Opposite effects of parity were also found for diagnosed hypertension. No interaction by menopausal status was found.; Our analyses yield differential effects of parity on BP in older vs. younger women. Reductions in BP in younger parous women have been described before; the opposite impact in older women is new. The findings may constitute biological mechanisms in an aging population or reflect birth cohort effects.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Dratva, Julia and Schindler, Christian and Künzli, Nino and Zemp Stutz, Elisabeth and Probst Hensch, Nicole and Schneider, Cornelia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:0263-6352
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:09 Oct 2018 12:14
Deposited On:07 Nov 2014 08:28

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